SB-203580, p38 MAP kinase inhibitor (TBI2173)
Care information
Care information
Display general product information or specific product information using metafields.
Delivery and Shipping
Delivery and Shipping
Add some general information about your delivery and shipping policies.
SB-203580, p38 MAP kinase inhibitor (TBI2173)
Payment & Security
Payment methods
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
Product Description
Description
Product Details
Formal Name: 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazoledihydro-imidazole-1-carbonyl]-piperazin-2-one
Molecular Formula: C21H16N3OSF
Formula Weight: 377.44
CAS Number: 152121-47-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Storage: -20°C
Stability: ≥ 2 years.
Applications
p38 MAP kinase inhibitor
Functions
A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38γ and δ at 10 μM. A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function.
Application Procedures
First dissolved in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
