17-AAG, > 98%

Name: 17-AAG, > 98%
Brand: GenDEPOT
SKU: BC001-010
Price: 155.0 USD
Availability: InStock

$155.00

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GenDEPOT

17-AAG, > 98%

From $155.00

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC₅₀ values of 5-6 nM. 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC₅₀ of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC₅₀ values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants.

Store at -20℃

IC₅₀	5 nM
Target	HSP90
Solubility	DMSO : 100 mg/mL (170.73 mM) Ethanol : 5 mg/mL (8.53 mM) Water : Insoluble
Alternative Names	NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin