2-APB, TRP blocker (TBI1212)

Description

Product Details

Formal Name: 2-Aminoethoxydiphenyl borate

Molecular Formula: C₁₄H₁₆BNO

Formula Weight: 225.10

CAS Number: 524-95-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

TRP blocker

Functions

Activator of TRPV1, V2 and V3 but not V4, V5 or V6. Has been demonstrated to potentiate the effect of capsain, protons and heat on TRPV1. Also blocks IP3 induced calcium release. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.