2’-Deoxy-5-fluorocytidine, Irreversible DNA methyltransferase inhibitor (TBI2685)

Description

Product Details

Formal Name: 5-fluoro-2’deoxycytidine

Alternate Names: FCDR; FdCyd; NSC-48006; Ro 5-1090

Molecular Formula: C₉H₁₂FN₃O₄

Formula Weight: 245.20

CAS Number: 10356-76-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Irreversible DNA methyltransferase inhibitor

Functions

A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors. Like 5’-Azacytidine and decitabine, 2’-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation. It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo.

Application Procedures

First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.