3-Methyladenine, PI3K inhibitor (TBI2686)
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3-Methyladenine, PI3K inhibitor (TBI2686)
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Product Description
Description
Product Details
Formal Name: 3-Methyl-3H-purin-6-amine
Alternate Names: 3-MA
Molecular Formula: C6H7N5
Formula Weight: 149.20
CAS Number: 5142-23-4
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 5 mg/ml), or in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
PI3K inhibitor
Functions
Inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K). Protects 1321N1 astrocytoma cells against pyocyanin and hydroxyphenazine-induced toxicity. Inhibition of autophagy by 3-MA leads to enhanced apoptosis induced by a variety of agents including celastrol, cisplatin and sorafenib in several different cell lines. Increases CHO cell monoclonal antibody output.
Application Procedures
First dissolved in Water (up to 5 mg/ml), or in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in water, DMSO or DMF may be stored at -20°C for up to 3 months.
