6BIO, GSK-3 inhibitor (TBI1400)

Description

Product Details

Formal Name: (2’Z,3’E)-6-Bromoindirubin-3’oxime

Molecular Formula: C₁₆H₁₀BrN₃O₂

Formula Weight: 356.18

CAS Number: 667463-62-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 4 mg/ml with warming).

Storage: -20°C

Stability: ≥ 1 year.

Applications

GSK-3 inhibitor

Functions

Potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM. The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. Promotes proliferation in mammalian cardiomyocytes A potent inhibitor of malignant lymphoid cell proliferation.

Application Procedures

First dissolved in DMSO (up to 15 mg/ml), or in Ethanol (up to 4 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.