Actinomycin D, Transcription inhibitor
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Actinomycin D, Transcription inhibitor
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Product Description
Description
Product Details
Molecular Formula: C62H86N12O16
Formula Weight: 1255.42
CAS Number: 50-76-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 2 mg/ml) or in Ethanol (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Transcription inhibitor
Functions
Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of RNA polymerase. Induces apoptosis in a variety of cancer cell lines via the intrinsic pathway. Upregulates proapoptotic PUMA and downregulates Bcl-2 mRNA in peripheral blood lymphocytes.
Application Procedures
First dissolved in DMSO (up to 2 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions are not stable and must be made fresh and used within one working day. Do not store solutions.
