AG-1517 HCl, EGFR Tyrosine kinase inhibitor (TBI1377)
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AG-1517 HCl, EGFR Tyrosine kinase inhibitor (TBI1377)
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Product Description
Description
Product Details
Formal Name: 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride
Alternate Names: PD153,053; SU-5271; Z-252868
Molecular Formula: C16H14BrN3O2
Formula Weight: 360.21
CAS Number: 153436-54-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
EGFR Tyrosine kinase inhibitor
Functions
An ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFRK), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation. Inhibits the growth of a number of cancer cell lines. An extremely useful tool for exploring EGF-mediated cellular signaling.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
