Altretamine, GPX4 inhibitor; Ferroptosis inducer (TBI5592)
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Altretamine, GPX4 inhibitor; Ferroptosis inducer (TBI5592)
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Product Description
Description
Product Details
Formal Name: N2,N2,N4,N4,N6,N6-Hexamethyl-1,3,5-triazine-2,4,6-triamine; 2,4,6-Tris(dimethylamino)-1,3,5-triazine
Alternate Names: Hexamethylmelamine; NSC-13875
Molecular Formula: C9H18N6
Formula Weight: 210.30
CAS Number: 645-05-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (40 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
GPX4 inhibitor; Ferroptosis inducer
Functions
Induces ferroptosis by inhibiting glutathione peroxidase 4 (GPX4) which causes accumulation of lipid hydroperoxides. Ferroptosis induction may be its mechanism of action as a cancer chemotherapeutic. Clinically useful agent for ovarian cancer.
Application Procedures
First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer.
