Bexarotene, Free acid

Name: Bexarotene, Free acid
Brand: GenDEPOT
SKU: BC005-100
Price: 138.0 USD
Availability: InStock

$138.00

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GenDEPOT

Bexarotene, Free acid

From $138.00

Bexarotene is a highly selective retinoid X receptor (RXR) agonist. It is an antineoplastic agent, already approved as an oral antineoplastic agent for cutaneous T cell lymphoma and being investigated against other cancers. A study has found that bexarotene in a mouse Alzheimer′s model lowered the most toxic form of β-amyloid peptide and increased cognitive ability. The activity in the mouse Alzheimer′s models are believed to be by activating PPARγ:RXR and LXR:RXR dimers which induces the expression of apoE and facilitates Aβ clearance and promotes microglial phagocytosis.

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