DNase I

Name: DNase I
Brand: GenDEPOT
SKU: DN102-001
Price: 1250.0 USD
Availability: InStock

$1,250.00

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GenDEPOT

DNase I

$1,250.00

DNase I is an endonuclease derived from bovine pancreas that will degrade double-stranded DNA in the presence of divalent cations, producing 3”-OH

oligonucleotides. Mg²⁺ in the reaction solution causes the enzyme to produce nicks in double-stranded DNA, while in the presence of Mn²⁺, DNase I cleaves both strands of the DNA.

DNase I is useful in nick translation for introducing single-stranded nicks that serve as primer sites for initiation of DNA synthesis and for cloning random DNA fragments by cleaving double-stranded DNA. DNase I is a chromatographically pure preparation. It is offered as lyophilized powder. For greatest stability, it is important that DNAse be dissolved at a concentration of at least 1mg/ml in 50% Glycerol with 20mM Tris-HCl, pH 7.5 and 1mM MgCl₂. This solution can be stored at -20^oC for at least a year.