Paclitaxel, >99.5%

Paclitaxel is an antitumor agent. Stabilizes microtubules and lowers the critical concentration for tubulin polyerization. Reversibly binds to polyerized tubulin.mInhibits protein isoprenylation and induces apoposis in PC-3 human prostatemcancer cells. 

The checkpoint of mitotic spindle assembly, aberrant activation ofmcyclin-dependent kinases (CKDs) and the c-Jun N-terminal/stress activated protein

kinase (JNK/SAPK) are involved in Paclitaxel-induced apoptosis.

Store at -20℃

Assay	>99.5%
Solubility	DMSO: 50 mg/mL (can be stored frozen for several months)
Biochem/physiol Actions	Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).